Published in BMC bioinformatics, 2018
In this paper, we propose an algorithm to tackle the challenge of determining the composition of a heterogeneous cancer tissue by utilizing the data of accurate, but high cost, single cell line cell-by-cell observation methods in low cost aggregate observation method for heterogeneous cancer cell mixtures to obtain their composition in a Bayesian framework.
Recommended citation: Ashish Katiyar, Anwoy Mohanty, Jianping Hua, Sima Chao, Rosana Lopes, Aniruddha Datta and Michael L. Bittner(2018). "A Bayesian approach to determine the composition of heterogeneous cancer tissue" BMC Bioinformatics. 2018;19(Suppl 3)1 https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2062-0